Is depression in those with Alzheimer’s Disease different to depression in those without dementia?

Background Depression in individuals with Alzheimer’s disease (AD) is common, distressing, difficult to treat, may increase carer burden and inadequately understood. It occurs more frequently AD than older adults without dementia. The reasons why some patients develop depression during others do not remain obscure. We aimed identify risk factors for using 3 large cohort studies assess whether these differed from those people normal cognition. Method used data dementia focused cohorts: ADNI (n = 665 AD, 669 cognition), NACC 698 711 cognition) BDR 757 AD). ratings were available the GDS & NPI addition Cornell. Intermittent was defined as one episode above threshold persistent ≥ 2 episodes. A cut-off of ≥8 Cornell Scale Dementia, ≥6 sub-scale ≥2 NPI-Q sub-scale. logistic regression a random-effects meta-analysis examine potential an interaction term look interactions between each factor presence cognitive impairment. Because we study any participants only visit excluded analysis, treated who did meet criteria caseness at point. Result In individual there no evidence difference but combining suggested clear differences e.g. gender (figure 1). Previous increased this information (OR 7.78 95%CI 4.03-15.03). Conclusion Risk appear differ per se supporting suggestions different pathological process. have identified that past history strongest development on cohort.